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News from the S-BIO Business Division, Sumitomo Bakelite Co. Ltd. |
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Introduction of Research
Paper Using PrimeSurface™ |
〜Study on the Effects of Oxidative and Inflammatory Stress in Osteoarthritis〜 |
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This month, we would like to introduce a paper published in scientific reports: Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence.
Osteoarthritis (OA), which is common in middle-aged and older adults, occurs when the bone, cartilage, and other tissues that make up joints degenerate and become deformed. Chondrocyte senescence is an important factor in the onset and progression of OA. In this study, the effects of oxidative and inflammatory stresses on cartilage cell aging using rat chondrocytes were compared.
PrimeSurface 96U plates were used to form 3D spheroids of rat chondrocytes. Oxidative and inflammatory stresses were added before or after spheroid formation, and the extracellular matrix (ECM) production and degradation of chondrocytes were evaluated. Oxidative stress suppressed cell proliferation and decreased ECM production, while inflammatory stress increased gene expression of SASP (senescence-associated secretory phenotype) factor and enhanced ECM degradation.
From this study it is suggested that oxidative stress and inflammatory stress have different effects on rat chondrocyte senescence and inflammatory stress, rather than oxidative stress, is the primary trigger of SASP in OA. |
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