This month, we would like to introduce a paper published in scientific reports:
Comparison of the effects　of oxidative and inflammatory　stresses on rat chondrocyte　senescence.

Osteoarthritis (OA), which is common in middle-aged and older adults, occurs when the bone, cartilage, and other tissues that make up joints degenerate and become deformed. Chondrocyte senescence is an important factor in the onset and progression of OA. In this study, the effects of oxidative and inflammatory stresses on cartilage cell aging using rat chondrocytes were compared.

PrimeSurface 96U plates were used to form 3D spheroids of rat chondrocytes. Oxidative and inflammatory stresses were added before or after spheroid formation, and the extracellular matrix (ECM) production and degradation of chondrocytes were evaluated. Oxidative stress suppressed cell proliferation and decreased ECM production, while inflammatory stress increased gene expression of SASP (senescence-associated secretory phenotype) factor and enhanced ECM degradation.

From this study it is suggested that oxidative stress and inflammatory stress have different effects on rat chondrocyte senescence and inflammatory stress, rather than oxidative stress, is the primary trigger of SASP in OA.

News about S-BIO.

We participated in the 2nd Hands-On Seminar organized by the Consortium for Safety Assessment using Human iPS Cells (CSAHi) MPS (Microphysiological Systems) team on August 2. It was aimed at the use of MPS for safety assessment in drug discovery research and we had the opportunity to introduce our MPS-related products.

The seminar was a great success, and nearly 40 people visited our Hands-On exhibit, and we received feedback from a variety of perspectives, ranging from usage questions to advice on developing applications we had not anticipated.

Hearing firsthand feedback from users and competitors in such an environment is extremely beneficial for our product development and leads to our own learning. We will continue to actively participate in events like this one to improve our products and applications. We also plan to organize events to promote the use of MPS in drug discovery.